Product Name: Recombinant Zebrafish VEGF 165

7. Handling and Storage:

Reviewed on: 27 February 2012

     Precautions for safe handling: No special measures required. No special precautions are necessary if used correctly.

     Information about protection against explosions and fires: No special measures required.

     Conditions for safe storage: Store according to product specifications.

8. Exposure Controls and Personal Protection:

     Control parameters: None known. Contains no substances with occupational exposure limits.

   Appropriate engineering controls: Follow usual standard laboratory practices. Use appropriate chemical resistant gloves, appropriate safety glasses and wear protective work clothing.

9. Physical and Chemical Properties:

     Appearance: Lyophilized white powder or clear liquid.                   Upper/lower flammability or explosive limits: Not available.

     Odor: Little to none                                                                           Vapor pressure/density: Not available.

     Odor threshold: Not available                                                         Relative Density: Not available.

     pH: Not available                                                                               Solubility in/Miscibility with Water: Not available.

     Melting point/freezing point: Not available.                                   Partition coefficient: noctanol/water: Not available

     Boiling point/Boiling range: Not available.                                     Auto igniting: Product is not self igniting.

     Flash point: Not available.                                                               Decomposition temperature: Not available.

     Evaporation rate: Undetermined.                                                   Viscosity: Not available.

     Flammability: Not available.

10. Stability and Reactivity:

     Reactivity: Stable under recommended transport and storage conditions.

     Chemical Stability: Stable under recommended storage and handling temperatures.

     Possible hazardous reactions: Hazardous reactions will not occur under normal transport or storage conditions.

     Incompatible materials to be avoided: Heat and moisture.

     Incompatible materials: Strong acids/alkalis, strong oxidizing/reducing agents.

     Hazardous decomposition products: In combustion may emit toxic fumes. No known decomposition information.

11. Toxicological Information:

     Acute toxicity: Classification criteria are not met based on available data.

     Skin irritant effect: Classification criteria are not met based on available data.

     Eye irritant effect: Classification criteria are not met based on available data.

     Sensitization: Classification criteria are not met based on available data.

     Mutagenicity: Classification criteria are not met based on available data.

     Carcinogenicity: Classification criteria are not met based on available data.

     Reproductive toxicity: Classification criteria are not met based on available data.

     Additional toxicological information: When used and handled according to specifications, the product does not have any harmful effects according to available information.

12. Ecological Information:

     Ecotoxicity: Undetermined.

     Biodegradability: Undetermined.

     Mobility: Undetermined.

Safety Data Sheet

Product Name: Recombinant Zebrafish VEGF 165

Reviewed on: 27 February 2012

13. Disposal Considerations:

     Disposal methods: Dispose of waste in accordance to applicable national, regional, or local regulations.

     Contaminated packaging: Dispose in the same manner as unused product.

     Special precautions: Dispose of small amounts of spilled material as described in section 6. Large spills must be dealt with separately by

qualified disposal personnel. Avoid dispersal of spilt material to soil, waterways, drains and sewers.

14. Transport Information:

     UN Number: Does not meet the criteria for classification as hazardous for transport.

     DOT regulations: ·Hazard class: None

     Land transport ADR/RID (cross-border): Not regulated.

     Maritime transport IMDG: Not regulated.

     Marine pollutant: No

     Air transport ICAO-TI and IATA-DGR: Not regulated.

     Transport/Additional information: Not dangerous according to the above specifications.

15. Regulations:

   US Federal and State Regulations

TSCA (Toxic Substances Control Act): This product is not listed.

SARA 313: This product is not listed.

SARA 311/312 Hazards: None known.

CERCLA Reportable Quantity: Unknown

California Proposition 65: This product is not listed on California’s listing of known or potential carcinogens.

16. Other Information:

   Notice to reader: To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.

Safety Data Sheet

Product Name: Recombinant Zebrafish VEGF 165

Reviewed on: 27 February 2012

1. Product Information

   GHS Product identifier: Recombinant Zebrafish VEGF 165

   Other means of identification: Catalog Number: 1247-ZV         Acetonitrile Solution - Liquid

   Application of the substance / the preparation: For Research Use Only

   Manufacturer/Supplier:

R&D Systems Inc.

614 McKinley Place N.E. Minneapolis, MN 55413

USA

▪ For product related questions call: 1-800-343-7475 or 1-612-379-2956, In Europe call: +44(0)1235-529449.

▪ Emergency information: In case of a chemical emergency, spill, leak, fire, or accident, call CHEMTREC at 1-800-424-9300 (USA or

Canada). Outside USA or Canada: +1 703-527-3887 (collect calls accepted).

2. Hazards Identification:

   Classification: Regulation (EC) No. 1272/2008 [CLP/GHS]: Acetonitrile Solution - Liquid

Flam. Liq. 2,

Acute Tox. 4, Oral Acute Tox. 4, Dermal Acute Tox. 4, Inhalation Eye Irrit. 2A

   Signal Word: DANGER

   Hazard statements: H225: Highly flammable liquid and vapor. H302: Harmful if swallowed. H312: Harmful in contact with skin.

H332: Harmful if inhaled. H319: Causes serious eye irritation.

   Precautionary statements:

Prevention: P280: Wear protective gloves/eye protection/face protection. P210: Keep away from heat, sparks, open flames and hot

surfaces. No smoking. P241: Use explosion-proof electrical, ventilating, lighting and all material-handling equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P233: Keep container tightly closed. P271: Use only outdoors or in a well-ventilated area. P261: Avoid breathing dust/fume/gas/mist/vapors and spray. P270: Do not eat, drink or smoke when using this product. P264: Wash hands thoroughly after handling.

Response:

IF INHALED:       Remove victim to fresh air and keep comfortable for breathing. Call a POISON CENTER or physician if you feel unwell.

IF SWALLOWED: Call a POISON CENTER or physician if you feel unwell. Rinse mouth.

IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash with plenty of soap and water. Call a POISON CENTER or physician if you feel unwell. Wash contaminated clothing before

reuse. If skin irritation occurs: Get medical attention. See specific treatment in this SDS.

IF IN EYES:       Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.

Continue rinsing. If eye irritation persists: Get medical attention/advice. IN CASE OF FIRE: Use dry chemical, CO2, or alcohol-resistant foam to extinguish.

   Classification according to Directive 1999/45/EC [DPD]: The product is classified as dangerous according to Directive 1999/45/EC and its amendments.

   Classification: F: Highly flammable. Xn: Harmful. Xi: Irritant. C: Corrosive