Product Name: Recombinant Cotton Rat CCL4/MIP-1 beta

Reviewed on: 27 February 2012

you feel unwell seek medical advice immediately. S61: Avoid release to the environment. Refer to special instructions/safety data sheet.

3. Information on Ingredients:

Description: Mixture of the substances listed below with nonhazardous additions.

4. First Aid Measures:

     Skin contact: Wash with plenty of soap and water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. Continue to rinse for at least 10 minutes. Get medical attention. If necessary, call a poison center or physician. Wash clothing before reuse. Clean shoes thoroughly before reuse.

     Ingestion:       Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable

for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention. If necessary, call a poison center or physician. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

   Protection of first-aiders: No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are

still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water before removing it, or wear gloves.

   Potential acute health effects:

Eye contact: Causes serious eye irritation.

Inhalation: Harmful if inhaled. Exposure to decomposition products may cause a health hazard. Serious effects may be delayed

following exposure.

Skin contact: Toxic in contact with skin. Causes skin irritation.

Ingestion: Harmful if swallowed. Irritating to mouth, throat and stomach.

   Over-exposure signs/symptoms:

Eye contact: Adverse symptoms may include the following: pain or irritation, watering, redness

Inhalation: No specific data.

Skin contact: Adverse symptoms may include the following: irritation, redness.

Ingestion: No specific data.

   Notes to physician: In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours.

   Specific treatments: No specific treatment.

Safety Data Sheet

Product Name: Recombinant Cotton Rat CCL4/MIP-1 beta

5. Fire Fighting Measures:

Reviewed on: 27 February 2012

   Suitable extinguishing agents: Dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected contain ers with flooding quantities of water. Apply water from as far a distance as possible.

   Special hazards arising from the substance or mixture: Emits toxic fumes under fire conditions. Carbon oxides.

   Protective equipment: Wear self contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

   Further information: Use water spray to cool unopened containers.

6. Accidental Release Measures:

      Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate all personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.

           Environmental precautions: Prevent further leakage or spillage is safe to do so. Do not let product enter drains. Discharge into the

environment must be avoided.

   Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum

cleaner or by wet-brushing and place in container for disposal according to local regulations.

7. Handling and Storage:

   Precautions for safe handling:

Protective measures: Put on appropriate personal protective equipment (see Section 8). Do not get in eyes or on skin or clothing. Do

not breathe vapor or mist. Do not ingest. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame or any other ignition source. Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Use only non-sparking tools. Take precautionary measures against electrostatic discharges. Empty containers retain product residue and can

be hazardous. Do not reuse container.

Advice on general occupational hygiene: Eating, drinking and smoking should be prohibited in areas where this material is handled,

stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

   Conditions for safe storage: Store in a well-ventilated place. Keep cool. Store in accordance with local regulations. Store in a segregated

and approved area. Store in original container protected from direct sunlight in a dry, cool and well ventilated area, away from incompatible materials (see section 10) and food and drink. Store locked up. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination.

8. Exposure Controls and Personal Protection:

   Control parameters:

Occupational exposure limits Product/ingredient name Exposure limit values

Acetonitrile (EH40/2005 WELs (United Kingdom (UK), 8/2007).

STEL: 102 mg/m³ 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 40 ppm 8 hour(s).

TWA: 68 mg/m³ 8 hour(s).

   Recommended monitoring procedures: If this product contains ingredients with exposure limits, personal, workplace atmosphere or

biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to European Standard EN 689 for methods for the assessment of exposure by inhalation to chemical agents and national guidance documents for methods for the determination of hazardous subs tances.

   Derived effect levels: No DELs available.

   Predicted effect concentrations: No PECs available.

Safety Data Sheet

Product Name: Recombinant Cotton Rat CCL4/MIP-1 beta

Reviewed on: 27 February 2012

   Exposure controls Appropriate engineering controls: Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. The engineering controls also need to keep gas, vapor or dust concentrations below any lower explosive limits. Use explosion -proof ventilation equipment.

Individual protection measures Hygiene measures: Wash hands, forearms and face thoroughly after handling chemical products,

before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

Eye/face protection: Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is

necessary to avoid exposure to liquid splashes, mists, gases or dusts.

Skin protection Hand protection: Chemical-resistant, impervious gloves complying with an approved standard should be worn at all

times when handling chemical products if a risk assessment indicates this is necessary.

Body protection: Personal protective equipment for the body should be selected based on the task being performed and the risks

involved and should be approved by a specialist before handling this product.

Other skin protection: Appropriate footwear and any additional skin protection measures should be selected based on the task being

performed and the risks involved and should be approved by a specialist before handling this product.

Respiratory protection: Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk

assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazar ds of the product and the safe working limits of the selected respirator.

Environmental exposure controls: Emissions from ventilation or work process equipment should be checked to ensure they comply

with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

9. Physical and Chemical Properties:

     Appearance: Colorless Liquid                                           Upper/lower flammability or explosive limits: Not available.

     Odor: Not available.                                                           Vapor pressure: 73 mmHg at 20o C.

     Odor threshold:                                                                 Vapor density : Not available

     pH: 2.0 ± 0.3                                                                       Relative density: 0.786 g/mL at 20o C.

     Melting point/freezing point: Undetermined.                   Solubility in/Miscibility with Water: Soluble.

     Boiling point/Boiling range: 82.0o C (180o F)                 Partition coefficient: noctanol/water: Not available.

     Flash point: 5° C                                                               Auto igniting: Product is not self igniting.

     Evaporation rate: Not available                                         Decomposition temperature: Not available

   Flammability (solid, gas): Not available.                         Viscosity: Undetermined.

10. Stability and Reactivity:

   Reactivity: No specific test data related to reactivity available for this product or its ingredients.

   Chemical Stability: Stable under normal ambient storage and handling temperatures.

   Possibility of hazardous reactions: Under normal conditions of storage and use, hazardous reactions will not occur.

   Conditions to be avoided: Avoid all possible sources of ignition (heat, spark, flame and direct sunlight).

   Incompatible materials to be avoided: Oxidizing or reducing materials, acids and bases, sulfites, perchlorates, alcohols and aluminum.

May attack many plastics, rubbers and coatings.

   Hazardous decomposition products: In case of fire hazardous decomposition products may be produced such as: Hydrogen cyanide

(hydrocyanic acid), carbon dioxide, carbon monoxide, oxides of nitrogen, dense black smoke.

11. Toxicological Information:

   Acute toxicity:

   Skin irritant effect: .Acetonitrile – Mild irritant rabbit

Safety Data Sheet

Product Name: Recombinant Cotton Rat CCL4/MIP-1 beta

   Eye irritant effect: Acetonitrile – Moderate irritant rabbit

   Sensitization: Not available.

   Mutagenicity: Not available.

   Carcinogenicity: Not available.

   Reproductive toxicity: Not available.

   Specific target organ toxicity (single exposure): Not available.

   Specific target organ toxicity (repeated exposure): Not available.

   Aspiration hazard: Not available.

   Information on likely routes of exposure: Routes of entry anticipated; oral, dermal, inhalation.

   Symptoms related to the physical, chemical and toxicological characteristics: Inhalation: No specific data.

Ingestion: No specific data.

Skin contact: Adverse symptoms may include the following: irritation, redness

Reviewed on: 27 February 2012

Eye contact: Adverse symptoms may include the following: pain or irritation, watering, redness

   Delayed and immediate effects and also chronic effects from short and long term exposure:

Short term exposure: Potential immediate effects: Not available. Potential delayed effects: Not available.

Long term exposure: Potential immediate effects: Not available. Potential delayed effects : Not available.

   Potential chronic health effects: Not available.

12. Ecological Information:

   Ecotoxicity:

Acetonitrile           Acute LC50 3600000 µg/L Fresh water Daphnia - Daphnia magna - <24 hours

Acute LC50 >1500 mg/L Fresh water Fish - Pimephales promelas - Juvenile) - 0.2 to 0.5 g at 96 hours

     Biodegradability:     Not available.

   Bioaccumulative potential: Acetonitrile – potential low.

     Mobility in soil:       Not available.

13. Disposal Considerations:

     Disposal methods: Dispose of waste in accordance to applicable national, regional, or local regulations.

     Hazardous waste: The classification of the product may meet the criteria for a hazardous waste.

     Special precautions: This material and its container must be disposed of in a safe way. Emptied containers should be cleaned or rinsed

out. Empty containers may retain some product residues. Vapor from product residues may create a highly flammable or explosive atmosphere inside the container. Avoid dispersal of spilt material to soil, waterways, drains and sewers.

14. Transport Information:

 ADR/RID ADN/ADNR IMDG IATA/DOT

Safety Data Sheet